Gluconeogenesis (De Novo Synthesis of Glucose)
Gluconeogenesis (De Novo Synthesis of Glucose) Glucose is a source of energy for the mammalian cells whose concentration is narrowly managed in their body while during the fasting stage this range is nearly dropped to the 3.9–5.6 mmol/L. So, the liver shift its metabolism towards gluconeogenesis to balance the euglycemia..... During the prolonged period of fasting, the shift towards the gluconeogensis is compulsion because it can be critical for neurons, medullary cells of kidney, and RBCs that solely use glucose for energy (1). As Reversal of Glycolysis Gluconeogenesis is reversal of glycolysis. The non-carbohydrates molecules like amino acids, lactate and glycerol can be converted into pyruvate, then enters into mitochondria and is carboxylated to OAA. Here, OAA is converted into malate and entered into the cytoplasm and again re-oxidized into OAA, which ultimately decarboxylated and then phosphorylated to phosphoenelpyruvate (PEP). Then, PEP enters into the gluconeogenic c...