kEY IRREVERSIBLE REACTIONS OF GLYCOLYSIS REACTIONS
What is Glycolysis? Glycolysis or Embden–Meyerhof–Parnas pathway was the first pathway elucidated. Meyerhof won the noble prize in 1922 in physiology and medicine for his discovery to find fixed relationship between lactic acid utilisation in muscles and expenditure of oxygen. The word glycolysis is derived from Greek word "glykys" means sweet and "lysis" means splitting. So, the glycolysis involves the splitting of 1 glucose molecule into 2 pyruvate molecules. Moving on the pyruvate have two fate, whether converted into the acetyl-CO-A in the presence of oxygen or Lactate in the absence of oxygen. Summarising the glycolysis, it involves the 10 reactions that take place in cytosol and generate 2 ATP molecules. Despite taking place in the cytosol, yet evolved even before oxygen was present in the Earth's atmosphere. Irreversible Reactions of Glycolysis Three irreversible reactions of glycolysis are regulatory steps involve 3 key enzymes hexokinase, phospho-fru...